4ICA

Crystal structure of a C-terminal truncated form of the matrix subunit (p15) of Feline Immunodeficiency Virus (FIV)

4ICA の概要

• エントリーDOI: 10.2210/pdb4ica/pdb
• 関連するPDBエントリー: 4IC9
• 分子名称: Matrix protein p15, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL (3 entities in total)
• 機能のキーワード: fiv, p15, retroviral matrix protein, viral protein
• 由来する生物種: Feline immunodeficiency virus (FIV)
• 細胞内の位置: Matrix protein p15: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p13: Virion (Potential): P16087
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30186.73

構造登録者

Serriere, J.,Robert, X.,Perez, M.,Gouet, P.,Guillon, C. (登録日: 2012-12-10, 公開日: 2013-07-10, 最終更新日: 2024-04-03)

主引用文献

Serriere, J.,Robert, X.,Perez, M.,Gouet, P.,Guillon, C.
Biophysical characterization and crystal structure of the Feline Immunodeficiency Virus p15 matrix protein.
Retrovirology, 10:64-64, 2013

PubMed Abstract: Feline Immunodeficiency Virus (FIV) is a viral pathogen that infects domestic cats and wild felids. During the viral replication cycle, the FIV p15 matrix protein oligomerizes to form a closed matrix that underlies the lipidic envelope of the virion. Because of its crucial role in the early and late stages of viral morphogenesis, especially in viral assembly, FIV p15 is an interesting target in the development of potential new therapeutic strategies.

PubMed: 23800358
DOI: 10.1186/1742-4690-10-64

実験手法

X-RAY DIFFRACTION (2.7 Å)