4IB4

Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine

4IB4 の概要

• エントリーDOI: 10.2210/pdb4ib4/pdb
• 分子名称: Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562, Ergotamine, PALMITIC ACID, ... (9 entities in total)
• 機能のキーワード: ergotamine, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, signaling protein, electron transport, gpcr dock
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Multi- pass membrane protein : P41595
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51711.33

構造登録者

Wacker, D.,Wang, C.,Katritch, V.,Han, G.W.,Huang, X.,Vardy, E.,McCorvy, J.D.,Jiang, Y.,Chu, M.,Siu, F.Y.,Liu, W.,Xu, H.E.,Cherezov, V.,Roth, B.L.,Stevens, R.C.,GPCR Network (GPCR) (登録日: 2012-12-07, 公開日: 2013-03-13, 最終更新日: 2023-09-20)

• 主引用文献: Wacker, D.,Wang, C.,Katritch, V.,Han, G.W.,Huang, X.P.,Vardy, E.,McCorvy, J.D.,Jiang, Y.,Chu, M.,Siu, F.Y.,Liu, W.,Xu, H.E.,Cherezov, V.,Roth, B.L.,Stevens, R.C.; Structural features for functional selectivity at serotonin receptors.; Science, 340:615-619, 2013; PubMed: 23519215; DOI: 10.1126/science.1232808

実験手法

X-RAY DIFFRACTION (2.7 Å)