Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target)

Summary for 4IAR

DescriptorChimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
Functional Keywordsergotamine, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, signaling protein, electron transport, gpcr dock
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Multi-pass membrane protein  P28222
Total number of polymer chains1
Total molecular weight46210.88
Primary citation
Wang, C.,Jiang, Y.,Ma, J.,Wu, H.,Wacker, D.,Katritch, V.,Han, G.W.,Liu, W.,Huang, X.P.,Vardy, E.,McCorvy, J.D.,Gao, X.,Zhou, X.E.,Melcher, K.,Zhang, C.,Bai, F.,Yang, H.,Yang, L.,Jiang, H.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,Xu, H.E.
Structural basis for molecular recognition at serotonin receptors.
Science, 340:610-614, 2013
PubMed: 23519210 (PDB entries with the same primary citation)
DOI: 10.1126/science.1232807
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.277407.9%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4iar
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Molmil generated image of 4iar
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Molmil generated image of 4iar
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