4IA9
Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide
Summary for 4IA9
Entry DOI | 10.2210/pdb4ia9/pdb |
Descriptor | WD repeat-containing protein 5, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | wdr5, structural genomics consortium, wd repeat domain 5, transcription, sgc |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P61964 |
Total number of polymer chains | 1 |
Total formula weight | 34820.86 |
Authors | Dong, A.,Dombrovski, L.,Bolshan, Y.,Getlik, M.,Tempel, W.,Kuznetsova, E.,Wasney, G.A.,Hajian, T.,Poda, G.,Nguyen, K.T.,Schapira, M.,Brown, P.J.,Al-awar, R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Smil, D.,Vedadi, M.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2012-12-06, release date: 2012-12-26, Last modification date: 2023-09-20) |
Primary citation | Bolshan, Y.,Getlik, M.,Kuznetsova, E.,Wasney, G.A.,Hajian, T.,Poda, G.,Nguyen, K.T.,Wu, H.,Dombrovski, L.,Dong, A.,Senisterra, G.,Schapira, M.,Arrowsmith, C.H.,Brown, P.J.,Al-Awar, R.,Vedadi, M.,Smil, D. Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett, 4:353-357, 2013 Cited by PubMed: 24900672DOI: 10.1021/ml300467n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
Download full validation report