4I8V

Human Cytochrome P450 1A1 in complex with alpha-naphthoflavone

Summary for 4I8V

Entry DOI	10.2210/pdb4i8v/pdb
Descriptor	Cytochrome P450 1A1, PROTOPORPHYRIN IX CONTAINING FE, 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, ... (5 entities in total)
Functional Keywords	monooxygenase, cytochrome p450, p450, cyp1a1, p450 1a1, heme, oxidoreductase, aryl hydrocarbon hydroxylase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P04798
Total number of polymer chains	4
Total formula weight	227517.78
Authors	Walsh, A.A.,Scott, E.E. (deposition date: 2012-12-04, release date: 2013-02-27, Last modification date: 2023-09-20)
Primary citation	Walsh, A.A.,Szklarz, G.D.,Scott, E.E. Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism. J.Biol.Chem., 288:12932-12943, 2013 Cited by PubMed: 23508959 DOI: 10.1074/jbc.M113.452953 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation