4I6F

Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain

4I6F の概要

• エントリーDOI: 10.2210/pdb4i6f/pdb
• 関連するPDBエントリー: 4I5M 4I5P 4I6B 4I6H
• 分子名称: Serine/threonine-protein kinase PLK2, (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-phenyl-1H-imidazol-1-yl)-7,8-dihydropteridin-6(5H)-one (3 entities in total)
• 機能のキーワード: polo-like kinase-2 (plk-2), synuclein, parkinsons disease, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole: Q9NYY3
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36234.68

構造登録者

Pan, H. (登録日: 2012-11-29, 公開日: 2013-11-20, 最終更新日: 2024-02-28)

• 主引用文献: Aubele, D.L.,Hom, R.K.,Adler, M.,Galemmo, R.A.,Bowers, S.,Truong, A.P.,Pan, H.,Beroza, P.,Neitz, R.J.,Yao, N.,Lin, M.,Tonn, G.,Zhang, H.,Bova, M.P.,Ren, Z.,Tam, D.,Ruslim, L.,Baker, J.,Diep, L.,Fitzgerald, K.,Hoffman, J.,Motter, R.,Fauss, D.,Tanaka, P.,Dappen, M.,Jagodzinski, J.,Chan, W.,Konradi, A.W.,Latimer, L.,Zhu, Y.L.,Sham, H.L.,Anderson, J.P.,Bergeron, M.,Artis, D.R.; Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain.; Chemmedchem, 8:1295-1313, 2013; PubMed: 23794260; DOI: 10.1002/cmdc.201300166

実験手法

X-RAY DIFFRACTION (2.9 Å)