4I5I
Crystal structure of the SIRT1 catalytic domain bound to NAD and an EX527 analog
4I5I の概要
エントリーDOI | 10.2210/pdb4i5i/pdb |
分子名称 | NAD-dependent protein deacetylase sirtuin-1, (6S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total) |
機能のキーワード | rossmann fold, histone deacetylase, epigenetics, cancer, sirtuin, acetylated lysine of histone, hydrolase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus, PML body. SirtT1 75 kDa fragment: Cytoplasm: Q96EB6 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 67024.58 |
構造登録者 | Zhao, X.,Allison, D.,Condon, B.,Zhang, F.,Gheyi, T.,Zhang, A.,Ashok, S.,Russell, M.,Macewan, I.,Qian, Y.,Jamison, J.A.,Luz, J.G. (登録日: 2012-11-28, 公開日: 2013-01-23, 最終更新日: 2023-09-20) |
主引用文献 | Zhao, X.,Allison, D.,Condon, B.,Zhang, F.,Gheyi, T.,Zhang, A.,Ashok, S.,Russell, M.,MacEwan, I.,Qian, Y.,Jamison, J.A.,Luz, J.G. The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition. J.Med.Chem., 56:963-969, 2013 Cited by PubMed: 23311358DOI: 10.1021/jm301431y 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.5 Å) |
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