4I53

Crystal structure of clade C1086 HIV-1 gp120 core in complex with DMJ-II-121

4I53 の概要

• エントリーDOI: 10.2210/pdb4i53/pdb
• 分子名称: HIV-1 glycoprotein, amino({[(1R,2R)-1-({[(4-chloro-3-fluorophenyl)amino](oxo)acetyl}amino)-2,3-dihydro-1H-inden-2-yl]methyl}amino)methanimi nium, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: hiv, gp120, entry inhibitor, dmj-ii-121, cd4-mimetic, viral protein-inhibitor complex, c1086, extracellular, viral protein/inhibitor
• 由来する生物種: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83242.75

構造登録者

Le-Khac, M.,Hendrickson, W.A. (登録日: 2012-11-28, 公開日: 2013-05-29, 最終更新日: 2021-05-26)

• 主引用文献: Lalonde, J.M.,Le-Khac, M.,Jones, D.M.,Courter, J.R.,Park, J.,Schon, A.,Princiotto, A.M.,Wu, X.,Mascola, J.R.,Freire, E.,Sodroski, J.,Madani, N.,Hendrickson, W.A.,Smith, A.B.; Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization.; ACS Med Chem Lett, 4:338-343, 2013; PubMed: 23667716; DOI: 10.1021/ml300407y

実験手法

X-RAY DIFFRACTION (2.5002 Å)