4I3Q
Crystal structure of human CYP3A4 coordinated to a water molecule
Summary for 4I3Q
| Entry DOI | 10.2210/pdb4i3q/pdb |
| Related | 1TQN 1WOE |
| Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total) |
| Functional Keywords | hemoprotein, monooxygenase, cytochrome p450 reductase, cytochrome b5, endoplasmic reticulum, cytochrome p450, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P08684 |
| Total number of polymer chains | 1 |
| Total formula weight | 56374.30 |
| Authors | Sevrioukova, I.F.,Poulos, T.L. (deposition date: 2012-11-26, release date: 2013-04-24, Last modification date: 2023-09-20) |
| Primary citation | Sevrioukova, I.F.,Poulos, T.L. Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir. J.Med.Chem., 56:3733-3741, 2013 Cited by PubMed: 23586711DOI: 10.1021/jm400288z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.602 Å) |
Structure validation
Download full validation report
