4I32
Crystal structure of HCV NS3/4A D168V protease complexed with compound 4
Summary for 4I32
Entry DOI | 10.2210/pdb4i32/pdb |
Descriptor | Genome polyprotein, HCV non-structural protein 4A, SODIUM ION, ... (5 entities in total) |
Functional Keywords | hepatitis c virus, ns3, ns4a, protein-inhibitor complex compound 4, serine protease, d168v, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepatitis C virus (HCV) More |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26662 P26662 |
Total number of polymer chains | 4 |
Total formula weight | 44847.20 |
Authors | Lemke, C.T. (deposition date: 2012-11-23, release date: 2013-01-02, Last modification date: 2013-03-13) |
Primary citation | O'Meara, J.A.,Lemke, C.T.,Godbout, C.,Kukolj, G.,Lagace, L.,Moreau, B.,Thibeault, D.,White, P.W.,Llinas-Brunet, M. Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance. J.Biol.Chem., 288:5673-5681, 2013 Cited by PubMed: 23271737DOI: 10.1074/jbc.M112.439455 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3001 Å) |
Structure validation
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