4I31
Crystal structure of HCV NS3/NS4A protease complexed with compound 4
4I31 の概要
エントリーDOI | 10.2210/pdb4i31/pdb |
分子名称 | Genome polyprotein, HCV non-structural protein 4A, SODIUM ION, ... (5 entities in total) |
機能のキーワード | hepatitis c virus, ns3, ns4a, protein-inhibitor complex compound 4, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Hepatitis C virus (HCV) 詳細 |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26662 P26662 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 44902.10 |
構造登録者 | |
主引用文献 | O'Meara, J.A.,Lemke, C.T.,Godbout, C.,Kukolj, G.,Lagace, L.,Moreau, B.,Thibeault, D.,White, P.W.,Llinas-Brunet, M. Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance. J.Biol.Chem., 288:5673-5681, 2013 Cited by PubMed: 23271737DOI: 10.1074/jbc.M112.439455 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9301 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード