4I2P

Crystal structure of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) based analogue

4I2P の概要

• エントリーDOI: 10.2210/pdb4i2p/pdb
• 分子名称: Gag-Pol polyprotein, (2E)-3-[4-({6-[(4-methoxyphenyl)amino]-7H-purin-2-yl}amino)-3,5-dimethylphenyl]prop-2-enenitrile, ... (4 entities in total)
• 機能のキーワード: p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 BH10 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114440.18

構造登録者

Patel, D.,Bauman, J.D.,Das, K.,Arnold, E. (登録日: 2012-11-22, 公開日: 2013-01-16, 最終更新日: 2024-02-28)

• 主引用文献: Johnson, B.C.,Pauly, G.T.,Rai, G.,Patel, D.,Bauman, J.D.,Baker, H.L.,Das, K.,Schneider, J.P.,Maloney, D.J.,Arnold, E.,Thomas, C.J.,Hughes, S.H.; A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.; Retrovirology, 9:99-99, 2012; PubMed: 23217210; DOI: 10.1186/1742-4690-9-99

実験手法

X-RAY DIFFRACTION (2.2964 Å)