4I2L

New HIV entry inhibitor MTSFT/T23 complex

4I2L の概要

• エントリーDOI: 10.2210/pdb4i2l/pdb
• 分子名称: GP41, inhibitor MTSFT (3 entities in total)
• 機能のキーワード: 6-helix bundle, coiled-coil, membrane, fusion inhibitor, m-t hook, 6-helix-bundle, tryptophan-methionine, viral protein-antiviral protein complex, viral protein/antiviral protein
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P04580
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 9651.84

構造登録者

Yao, X.,Chong, H.H.,Waltersperger, S.,Wang, M.T.,He, Y.X.,Cui, S. (登録日: 2012-11-22, 公開日: 2014-01-22, 最終更新日: 2023-11-08)

• 主引用文献: Yao, X.,Chong, H.H.,Waltersperger, S.,Wang, M.T.,He, Y.X.,Cui, S.; Potent antiviral activity of the novel HIV entry inhibitor MTSFT; To be Published,

実験手法

X-RAY DIFFRACTION (1.426 Å)