4I1S

Melanoma differentiation associated protein-5 Helicase domain complex with inhibitor Non-structural protein V

Summary for 4I1S

• Entry DOI: 10.2210/pdb4i1s/pdb
• Descriptor: Melanoma differentiation associated protein-5, Non-structural protein V, ZINC ION, ... (4 entities in total)
• Functional Keywords: sf2-atpase, helicase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Sus scrofa (pigs,swine,wild boar); More
• Cellular location: Host cytoplasm : P11207
• Total number of polymer chains: 2
• Total formula weight: 34562.13

Authors

Motz, C.,Witte, G.,Hopfner, K.P. (deposition date: 2012-11-21, release date: 2013-01-30, Last modification date: 2017-07-26)

• Primary citation: Motz, C.,Schuhmann, K.M.,Kirchhofer, A.,Moldt, M.,Witte, G.,Conzelmann, K.K.,Hopfner, K.P.; Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.; Science, 339:690-693, 2013; PubMed: 23328395; DOI: 10.1126/science.1230949

Experimental method

X-RAY DIFFRACTION (2.293 Å)