4I18

Crystal structure of human prolactin receptor complexed with Fab fragment

4I18 の概要

• エントリーDOI: 10.2210/pdb4i18/pdb
• 分子名称: antibody light chain, antibody heavy chain, Prolactin receptor, ... (6 entities in total)
• 機能のキーワード: immunoglobulin fold, prolactin binding, receptor signaling, cytokine, signaling protein
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Membrane ; Single-pass type I membrane protein . Isoform 7: Secreted: P16471
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 147487.81

構造登録者

Duguid, E.M.,Mukherjee, S.,Kouadio, J.L. (登録日: 2012-11-20, 公開日: 2013-11-20, 最終更新日: 2024-10-16)

主引用文献

Rizk, S.S.,Kouadio, J.L.,Szymborska, A.,Duguid, E.M.,Mukherjee, S.,Zheng, J.,Clevenger, C.V.,Kossiakoff, A.A.
Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling.
Cell Commun Signal, 13:1-1, 2015

PubMed Abstract: Many receptors function by binding to multiple ligands, each eliciting a distinct biological output. The extracellular domain of the human prolactin receptor (hPRL-R) uses an identical epitope to bind to both prolactin (hPRL) and growth hormone (hGH), yet little is known about how each hormone binding event triggers the appropriate response.

PubMed: 25589173
DOI: 10.1186/s12964-014-0080-8

実験手法

X-RAY DIFFRACTION (3.238 Å)