4I15
Crystal structure of TbrPDEB1
Summary for 4I15
Entry DOI | 10.2210/pdb4i15/pdb |
Descriptor | Class 1 phosphodiesterase PDEB1, ZINC ION, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | parasite pde, sleeping sickness, african trypanosomiasis, hydrolase |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 2 |
Total formula weight | 77628.00 |
Authors | |
Primary citation | Jansen, C.,Wang, H.,Kooistra, A.J.,de Graaf, C.,Orrling, K.M.,Tenor, H.,Seebeck, T.,Bailey, D.,de Esch, I.J.,Ke, H.,Leurs, R. Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure. J.Med.Chem., 56:2087-2096, 2013 Cited by PubMed: 23409953DOI: 10.1021/jm3017877 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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