4I15

Crystal structure of TbrPDEB1

Summary for 4I15

Entry DOI	10.2210/pdb4i15/pdb
Descriptor	Class 1 phosphodiesterase PDEB1, ZINC ION, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	parasite pde, sleeping sickness, african trypanosomiasis, hydrolase
Biological source	Trypanosoma brucei
Total number of polymer chains	2
Total formula weight	77628.00
Authors	Wang, H.,Ke, H. (deposition date: 2012-11-20, release date: 2013-03-13, Last modification date: 2024-02-28)
Primary citation	Jansen, C.,Wang, H.,Kooistra, A.J.,de Graaf, C.,Orrling, K.M.,Tenor, H.,Seebeck, T.,Bailey, D.,de Esch, I.J.,Ke, H.,Leurs, R. Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure. J.Med.Chem., 56:2087-2096, 2013 Cited by PubMed: 23409953 DOI: 10.1021/jm3017877 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation