4I0T
Crystal structure of spleen tyrosine kinase complexed with 2-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide
Summary for 4I0T
Entry DOI | 10.2210/pdb4i0t/pdb |
Related | 4I0R 4I0S |
Descriptor | Tyrosine-protein kinase SYK, N-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (3 entities in total) |
Functional Keywords | kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 1 |
Total formula weight | 34222.41 |
Authors | Kuglstatter, A.,Slade, M. (deposition date: 2012-11-19, release date: 2013-10-30, Last modification date: 2023-09-20) |
Primary citation | Padilla, F.,Bhagirath, N.,Chen, S.,Chiao, E.,Goldstein, D.M.,Hermann, J.C.,Hsu, J.,Kennedy-Smith, J.J.,Kuglstatter, A.,Liao, C.,Liu, W.,Lowrie, L.E.,Luk, K.C.,Lynch, S.M.,Menke, J.,Niu, L.,Owens, T.D.,O-Yang, C.,Railkar, A.,Schoenfeld, R.C.,Slade, M.,Steiner, S.,Tan, Y.C.,Villasenor, A.G.,Wang, C.,Wanner, J.,Xie, W.,Xu, D.,Zhang, X.,Zhou, M.,Lucas, M.C. Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors. J.Med.Chem., 56:1677-1692, 2013 Cited by PubMed: 23350847DOI: 10.1021/jm301720p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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