4I0T

Crystal structure of spleen tyrosine kinase complexed with 2-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide

4I0T の概要

• エントリーDOI: 10.2210/pdb4i0t/pdb
• 関連するPDBエントリー: 4I0R 4I0S
• 分子名称: Tyrosine-protein kinase SYK, N-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (3 entities in total)
• 機能のキーワード: kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane : P43405
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34222.41

構造登録者

Kuglstatter, A.,Slade, M. (登録日: 2012-11-19, 公開日: 2013-10-30, 最終更新日: 2023-09-20)

• 主引用文献: Padilla, F.,Bhagirath, N.,Chen, S.,Chiao, E.,Goldstein, D.M.,Hermann, J.C.,Hsu, J.,Kennedy-Smith, J.J.,Kuglstatter, A.,Liao, C.,Liu, W.,Lowrie, L.E.,Luk, K.C.,Lynch, S.M.,Menke, J.,Niu, L.,Owens, T.D.,O-Yang, C.,Railkar, A.,Schoenfeld, R.C.,Slade, M.,Steiner, S.,Tan, Y.C.,Villasenor, A.G.,Wang, C.,Wanner, J.,Xie, W.,Xu, D.,Zhang, X.,Zhou, M.,Lucas, M.C.; Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.; J.Med.Chem., 56:1677-1692, 2013; PubMed: 23350847; DOI: 10.1021/jm301720p

実験手法

X-RAY DIFFRACTION (1.7 Å)