4HXN
Brd4 Bromodomain 1 complex with 4-(2-FLUOROPHENYL)-1,3-THIAZOL-2(3H)-ONE inhibitor
Summary for 4HXN
| Entry DOI | 10.2210/pdb4hxn/pdb |
| Related | 4HXK 4HXL 4HXM 4HXO 4HXP 4HXR 4HXS |
| Descriptor | Bromodomain-containing protein 4, 4-(2-fluorophenyl)-1,3-thiazol-2(3H)-one (3 entities in total) |
| Functional Keywords | brd4, bromodomain, four alpha helices, protein binding-inhibitor complex, protein binding/inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus (By similarity): O60885 |
| Total number of polymer chains | 1 |
| Total formula weight | 15078.40 |
| Authors | Chen, T.T.,Cao, D.Y.,Chen, W.Y.,Xiong, B.,Shen, J.K.,Xu, Y.C. (deposition date: 2012-11-12, release date: 2013-04-03, Last modification date: 2024-02-28) |
| Primary citation | Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem., 56:3833-3851, 2013 Cited by PubMed: 23530754DOI: 10.1021/jm301793a PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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