4HW3

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

4HW3 の概要

• エントリーDOI: 10.2210/pdb4hw3/pdb
• 関連するPDBエントリー: 4HW2 4HW4
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, 3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-benzothiophene-2-carboxylic acid (3 entities in total)
• 機能のキーワード: regulation of apoptosis, maintenance of viability, apoptosis, apoptosis-inhibitor complex, apoptosis/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass membrane protein (Potential): Q07820
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 214425.44

構造登録者

Zhao, B. (登録日: 2012-11-07, 公開日: 2013-01-09, 最終更新日: 2024-02-28)

• 主引用文献: Friberg, A.,Vigil, D.,Zhao, B.,Daniels, R.N.,Burke, J.P.,Garcia-Barrantes, P.M.,Camper, D.,Chauder, B.A.,Lee, T.,Olejniczak, E.T.,Fesik, S.W.; Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.; J.Med.Chem., 56:15-30, 2013; PubMed: 23244564; DOI: 10.1021/jm301448p

実験手法

X-RAY DIFFRACTION (2.4 Å)