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4HVS

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX647

Summary for 4HVS
Entry DOI10.2210/pdb4hvs/pdb
DescriptorMast/stem cell growth factor receptor Kit, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine (3 entities in total)
Functional Keywordstransferase, tyrosine-protein kinase, atp-binding, kinase-kinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cytoplasm: P10721
Total number of polymer chains1
Total formula weight38424.48
Authors
Zhang, Y.,Zhang, C. (deposition date: 2012-11-06, release date: 2013-03-27, Last modification date: 2023-09-20)
Primary citationZhang, C.,Ibrahim, P.N.,Zhang, J.,Burton, E.A.,Habets, G.,Zhang, Y.,Powell, B.,West, B.L.,Matusow, B.,Tsang, G.,Shellooe, R.,Carias, H.,Nguyen, H.,Marimuthu, A.,Zhang, K.Y.,Oh, A.,Bremer, R.,Hurt, C.R.,Artis, D.R.,Wu, G.,Nespi, M.,Spevak, W.,Lin, P.,Nolop, K.,Hirth, P.,Tesch, G.H.,Bollag, G.
Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proc.Natl.Acad.Sci.USA, 110:5689-5694, 2013
Cited by
PubMed: 23493555
DOI: 10.1073/pnas.1219457110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

數據於2024-03-27公開中

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