4HVS

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX647

4HVS の概要

• エントリーDOI: 10.2210/pdb4hvs/pdb
• 分子名称: Mast/stem cell growth factor receptor Kit, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine (3 entities in total)
• 機能のキーワード: transferase, tyrosine-protein kinase, atp-binding, kinase-kinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cytoplasm: P10721
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38424.48

構造登録者

Zhang, Y.,Zhang, C. (登録日: 2012-11-06, 公開日: 2013-03-27, 最終更新日: 2023-09-20)

• 主引用文献: Zhang, C.,Ibrahim, P.N.,Zhang, J.,Burton, E.A.,Habets, G.,Zhang, Y.,Powell, B.,West, B.L.,Matusow, B.,Tsang, G.,Shellooe, R.,Carias, H.,Nguyen, H.,Marimuthu, A.,Zhang, K.Y.,Oh, A.,Bremer, R.,Hurt, C.R.,Artis, D.R.,Wu, G.,Nespi, M.,Spevak, W.,Lin, P.,Nolop, K.,Hirth, P.,Tesch, G.H.,Bollag, G.; Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.; Proc.Natl.Acad.Sci.USA, 110:5689-5694, 2013; PubMed: 23493555; DOI: 10.1073/pnas.1219457110

実験手法

X-RAY DIFFRACTION (1.9 Å)