4HVB

Catalytic unit of PI3Kg in complex with PI3K/mTOR dual inhibitor PF-04979064

4HVB の概要

• エントリーDOI: 10.2210/pdb4hvb/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 1-{1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-3-methyl-8-(6-methylpyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one (3 entities in total)
• 機能のキーワード: lipid kinase, kinase, phosphoinositide kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111202.67

構造登録者

Knighton, D.R.,Cheng, H. (登録日: 2012-11-05, 公開日: 2013-11-20, 最終更新日: 2024-02-28)

• 主引用文献: Cheng, H.,Li, C.,Bailey, S.,Baxi, S.M.,Goulet, L.,Guo, L.,Hoffman, J.,Jiang, Y.,Johnson, T.O.,Johnson, T.W.,Knighton, D.R.,Li, J.,Liu, K.K.,Liu, Z.,Marx, M.A.,Walls, M.,Wells, P.A.,Yin, M.J.,Zhu, J.,Zientek, M.; Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.; ACS Med Chem Lett, 4:91-97, 2013; PubMed: 24900568; DOI: 10.1021/ml300309h

実験手法

X-RAY DIFFRACTION (2.35 Å)