4HVA
Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
Summary for 4HVA
Entry DOI | 10.2210/pdb4hva/pdb |
Related PRD ID | PRD_000960 |
Descriptor | Caspase-6, VEID Inhibitor, N-[(2R)-1-(3-cyanophenyl)-3-hydroxypropan-2-yl]-5-(3,4-dimethoxyphenyl)furan-3-carboxamide, ... (4 entities in total) |
Functional Keywords | caspase-6, active, veid, uncompetitive inhibition, ternary complex, caspase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P55212 |
Total number of polymer chains | 4 |
Total formula weight | 63327.06 |
Authors | |
Primary citation | Heise, C.E.,Murray, J.,Augustyn, K.E.,Bravo, B.,Chugha, P.,Cohen, F.,Giannetti, A.M.,Gibbons, P.,Hannoush, R.N.,Hearn, B.R.,Jaishankar, P.,Ly, C.Q.,Shah, K.,Stanger, K.,Steffek, M.,Tang, Y.,Zhao, X.,Lewcock, J.W.,Renslo, A.R.,Flygare, J.,Arkin, M.R. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One, 7:e50864-e50864, 2012 Cited by PubMed: 23227217DOI: 10.1371/journal.pone.0050864 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.074 Å) |
Structure validation
Download full validation report