4HVA

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

4HVA の概要

• エントリーDOI: 10.2210/pdb4hva/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000960
• 分子名称: Caspase-6, VEID Inhibitor, N-[(2R)-1-(3-cyanophenyl)-3-hydroxypropan-2-yl]-5-(3,4-dimethoxyphenyl)furan-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: caspase-6, active, veid, uncompetitive inhibition, ternary complex, caspase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P55212
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 63327.06

構造登録者

Murray, J.M.,Steffek, M. (登録日: 2012-11-05, 公開日: 2013-03-20)

• 主引用文献: Heise, C.E.,Murray, J.,Augustyn, K.E.,Bravo, B.,Chugha, P.,Cohen, F.,Giannetti, A.M.,Gibbons, P.,Hannoush, R.N.,Hearn, B.R.,Jaishankar, P.,Ly, C.Q.,Shah, K.,Stanger, K.,Steffek, M.,Tang, Y.,Zhao, X.,Lewcock, J.W.,Renslo, A.R.,Flygare, J.,Arkin, M.R.; Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.; Plos One, 7:e50864-e50864, 2012; PubMed: 23227217; DOI: 10.1371/journal.pone.0050864

実験手法

X-RAY DIFFRACTION (2.074 Å)