4HM9

Crystal structure of full-length human catenin-beta-like 1

4HM9 の概要

• エントリーDOI: 10.2210/pdb4hm9/pdb
• 分子名称: Beta-catenin-like protein 1 (1 entity in total)
• 機能のキーワード: all alpha-helical, armadillo repeats, protein transport
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q8WYA6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 65689.78

構造登録者

Du, Z.,Huang, X.,Wang, G.,Wu, Y. (登録日: 2012-10-18, 公開日: 2013-07-31, 最終更新日: 2024-02-28)

主引用文献

Huang, X.,Wang, G.,Wu, Y.,Du, Z.
The structure of full-length human CTNNBL1 reveals a distinct member of the armadillo-repeat protein family.
Acta Crystallogr.,Sect.D, 69:1598-1608, 2013

PubMed Abstract: Catenin-β-like protein 1 (CTNNBL1) is a highly conserved protein with multiple functions, one of which is to act as an interaction partner of the antibody-diversification enzyme activation-induced cytidine deaminase (AID) for its nuclear import and subnuclear trafficking. Here, the crystal structure of full-length human CTNNBL1 is reported. The protein contains six armadillo (ARM) repeats that pack into a superhelical ARM domain. This ARM domain is unique within the ARM protein family owing to the presence of several unusual structural features. Moreover, CTNNBL1 contains significant and novel non-ARM structures flanking both ends of the central ARM domain. A strong continuous hydrophobic core runs through the whole structure, indicating that the ARM and non-ARM structures fold together to form an integral structure. This structure defines a highly restrictive and discriminatory protein-binding groove that is not observed in other ARM proteins. The presence of a cluster of histidine residues in the groove implies a pH-sensitive histidine-mediated mechanism that may regulate protein binding activity. The many unique structural features of CTNNBL1 establish it as a distinct member of the ARM protein family. The structure provides critical insights into the molecular interactions between CTNNBL1 and its protein partners, especially AID.

PubMed: 23897482
DOI: 10.1107/S0907444913011360

実験手法

X-RAY DIFFRACTION (3.1001 Å)