4HLW

Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzoimidazole derivatives.

4HLW の概要

• エントリーDOI: 10.2210/pdb4hlw/pdb
• 分子名称: Androgen receptor, TESTOSTERONE, 2-[(2-phenoxyethyl)sulfanyl]-1H-benzimidazole, ... (6 entities in total)
• 機能のキーワード: nuclear hormone receptor, androgen binding domain, transcriptional factor, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P10275
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30615.88

構造登録者

Ravi, S.N.M.,Leblanc, E.,Axerio-Cilies, P.,Labriere, C.,Frewin, K.,Hassona, M.D.H.,Lack, N.A.,Han, F.Q.,Guns, E.S.,Young, R.,Ban, F.,Rennie, P.S.,Cherkasov, A. (登録日: 2012-10-17, 公開日: 2013-01-23, 最終更新日: 2024-02-28)

• 主引用文献: Munuganti, R.S.,Leblanc, E.,Axerio-Cilies, P.,Labriere, C.,Frewin, K.,Singh, K.,Hassona, M.D.,Lack, N.A.,Li, H.,Ban, F.,Tomlinson Guns, E.,Young, R.,Rennie, P.S.,Cherkasov, A.; Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole Derivatives.; J.Med.Chem., 56:1136-1148, 2013; PubMed: 23301637; DOI: 10.1021/jm3015712

実験手法

X-RAY DIFFRACTION (2.5 Å)