4HJD
GCN4pLI derivative with alpha/beta/acyclic-gamma amino acid substitution pattern
Summary for 4HJD
| Entry DOI | 10.2210/pdb4hjd/pdb |
| Related | 4HJB |
| Descriptor | GCN4pLI(alpha/beta/acyclic gamma) (2 entities in total) |
| Functional Keywords | alpha/beta/gamma amino acid, unknown function |
| Total number of polymer chains | 2 |
| Total formula weight | 7995.75 |
| Authors | Shin, Y.H.,Mortenson, D.E.,Satyshur, K.A.,Forest, K.T.,Gellman, S.H. (deposition date: 2012-10-12, release date: 2013-06-12, Last modification date: 2023-11-15) |
| Primary citation | Shin, Y.H.,Mortenson, D.E.,Satyshur, K.A.,Forest, K.T.,Gellman, S.H. Differential Impact of beta and gamma Residue Preorganization on alpha / beta / gamma-Peptide Helix Stability in Water. J.Am.Chem.Soc., 135:8149-8152, 2013 Cited by PubMed Abstract: Cyclic constraints have proven to be very effective for preorganizing β-amino acid residues and thereby stabilizing β- and α/β-peptide helices, but little is known about possible preorganization effects among γ residues. Here we assess and compare the impact of cyclic preorganization of β and γ residues in the context of a specific α/β/γ-peptide helix. The results show that β residue preorganization is critical for helix stability but that γ residue preorganization is less important. PubMed: 23701135DOI: 10.1021/ja403319q PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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