4HJD

GCN4pLI derivative with alpha/beta/acyclic-gamma amino acid substitution pattern

4HJD の概要

• エントリーDOI: 10.2210/pdb4hjd/pdb
• 関連するPDBエントリー: 4HJB
• 分子名称: GCN4pLI(alpha/beta/acyclic gamma) (2 entities in total)
• 機能のキーワード: alpha/beta/gamma amino acid, unknown function
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7995.75

構造登録者

Shin, Y.H.,Mortenson, D.E.,Satyshur, K.A.,Forest, K.T.,Gellman, S.H. (登録日: 2012-10-12, 公開日: 2013-06-12, 最終更新日: 2023-11-15)

主引用文献

Shin, Y.H.,Mortenson, D.E.,Satyshur, K.A.,Forest, K.T.,Gellman, S.H.
Differential Impact of beta and gamma Residue Preorganization on alpha / beta / gamma-Peptide Helix Stability in Water.
J.Am.Chem.Soc., 135:8149-8152, 2013

PubMed Abstract: Cyclic constraints have proven to be very effective for preorganizing β-amino acid residues and thereby stabilizing β- and α/β-peptide helices, but little is known about possible preorganization effects among γ residues. Here we assess and compare the impact of cyclic preorganization of β and γ residues in the context of a specific α/β/γ-peptide helix. The results show that β residue preorganization is critical for helix stability but that γ residue preorganization is less important.

PubMed: 23701135
DOI: 10.1021/ja403319q

実験手法

X-RAY DIFFRACTION (1.7 Å)