4HJC

Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)

4HJC の概要

• エントリーDOI: 10.2210/pdb4hjc/pdb
• 関連するPDBエントリー: 4HJ1
• 分子名称: ENVELOPE GLYCOPROTEIN (2 entities in total)
• 機能のキーワード: virus entry, class ii fusion protein, membrane fusion, viral membrane, viral protein
• 由来する生物種: Rift Valley fever virus (RVFV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46586.32

構造登録者

Dessau, M.,Modis, Y. (登録日: 2012-10-12, 公開日: 2013-01-16, 最終更新日: 2024-11-20)

主引用文献

Dessau, M.,Modis, Y.
Crystal structure of glycoprotein C from Rift Valley fever virus.
Proc.Natl.Acad.Sci.USA, 110:1696-1701, 2013

PubMed Abstract: Rift Valley fever virus (RVFV), like many other Bunyaviridae family members, is an emerging human and animal pathogen. Bunyaviruses have an outer lipid envelope bearing two glycoproteins, G(N) and G(C), required for cell entry. Bunyaviruses deliver their genome into the host-cell cytoplasm by fusing their envelope with an endosomal membrane. The molecular mechanism of this key entry step is unknown. The crystal structure of RVFV G(C) reveals a class II fusion protein architecture found previously in flaviviruses and alphaviruses. The structure identifies G(C) as the effector of membrane fusion and provides a direct view of the membrane anchor that initiates fusion. A structure of nonglycosylated G(C) reveals an extended conformation that may represent a fusion intermediate. Unanticipated similarities between G(C) and flavivirus envelope proteins reveal an evolutionary link between the two virus families and provide insights into the organization of G(C) in the outer shell of RVFV.

PubMed: 23319635
DOI: 10.1073/pnas.1217780110

実験手法

X-RAY DIFFRACTION (4.15 Å)