4HIV

Structure of actinomycin D d(ATGCGGCAT) complex

Summary for 4HIV

• Entry DOI: 10.2210/pdb4hiv/pdb
• Related PRD ID: PRD_000001
• Descriptor: DNA (5'-D(*AP*TP*GP*CP*GP*GP*CP*AP*T)-3'), ACTINOMYCIN D (3 entities in total)
• Functional Keywords: double helix dna, nucleotide flipping-out, sharp kink, left-handed twist, cgg tripleat repeat, neurological disease, dna-antibiotic complex, dna/antibiotic
• Biological source: Streptomyces antibioticus
• Total number of polymer chains: 4
• Total formula weight: 8030.54

Authors

Lo, Y.S.,Tseng, W.H.,Hou, M.H. (deposition date: 2012-10-12, release date: 2013-05-08, Last modification date: 2023-11-15)

• Primary citation: Lo, Y.S.,Tseng, W.H.,Chuang, C.Y.,Hou, M.H.; The structural basis of actinomycin D-binding induces nucleotide flipping out, a sharp bend and a left-handed twist in CGG triplet repeats.; Nucleic Acids Res., 41:4284-4294, 2013; PubMed: 23408860; DOI: 10.1093/nar/gkt084

Experimental method

X-RAY DIFFRACTION (2.6 Å)