4HHY
Crystal structure of PARP catalytic domain in complex with novel inhibitors
4HHY の概要
エントリーDOI | 10.2210/pdb4hhy/pdb |
分子名称 | Poly [ADP-ribose] polymerase 1, (9aR)-1-[(1-{2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl}piperidin-4-yl)carbonyl]-1,2,3,8,9,9a-hexahydro-7H-benzo[de][1,7]naphthyridin-7-one, SULFATE ION, ... (5 entities in total) |
機能のキーワード | polymerase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus: P09874 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 160937.78 |
構造登録者 | |
主引用文献 | Ye, N.,Chen, C.H.,Chen, T.,Song, Z.,He, J.X.,Huan, X.J.,Song, S.S.,Liu, Q.,Chen, Y.,Ding, J.,Xu, Y.,Miao, Z.H.,Zhang, A. Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors. J.Med.Chem., 56:2885-2903, 2013 Cited by PubMed: 23473053DOI: 10.1021/jm301825t 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.3637 Å) |
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