4HCQ

Crystal structure of GLMU from mycobacterium tuberculosis in complex with glucosamine-1-phosphate

4HCQ の概要

• エントリーDOI: 10.2210/pdb4hcq/pdb
• 分子名称: Bifunctional protein GlmU, 2-acetamido-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, COBALT (II) ION, ... (5 entities in total)
• 機能のキーワード: acetyltransferase, bifunctional, pyrophosphorylase, rossmann-like fold, left-handed-beta-helix, cell shape, cell wall biogenesis/degradation, magnesium, metal-binding, multifunctional enzyme, nucleotidyltransferase, peptidoglycan synthesis, transferase, acyltransferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53176.52

構造登録者

Jagtap, P.K.A.,Verma, S.K.,Vithani, N. (登録日: 2012-10-01, 公開日: 2013-03-13, 最終更新日: 2023-11-08)

• 主引用文献: Jagtap, P.K.A.,Verma, S.K.,Vithani, N.,Bais, V.S.,Prakash, B.; Crystal structures identify an atypical two-metal-ion mechanism for uridyltransfer in GlmU: its significance to sugar nucleotidyl transferases; J.Mol.Biol., 425:1745-1759, 2013; PubMed: 23485416; DOI: 10.1016/j.jmb.2013.02.019

実験手法

X-RAY DIFFRACTION (2.6 Å)