4HBP
Crystal Structure of FAAH in complex with inhibitor
Summary for 4HBP
Entry DOI | 10.2210/pdb4hbp/pdb |
Descriptor | Fatty-acid amide hydrolase 1, 4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide (3 entities in total) |
Functional Keywords | fatty acid amide hydrolase, amidase activity, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P97612 |
Total number of polymer chains | 2 |
Total formula weight | 121784.58 |
Authors | Behnke, C.,Skene, R.J. (deposition date: 2012-09-28, release date: 2013-02-06, Last modification date: 2023-09-20) |
Primary citation | Kono, M.,Matsumoto, T.,Kawamura, T.,Nishimura, A.,Kiyota, Y.,Oki, H.,Miyazaki, J.,Igaki, S.,Behnke, C.A.,Shimojo, M.,Kori, M. Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem., 21:28-41, 2013 Cited by PubMed: 23218778DOI: 10.1016/j.bmc.2012.11.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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