4HBP

Crystal Structure of FAAH in complex with inhibitor

Summary for 4HBP

Entry DOI	10.2210/pdb4hbp/pdb
Descriptor	Fatty-acid amide hydrolase 1, 4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide (3 entities in total)
Functional Keywords	fatty acid amide hydrolase, amidase activity, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
Total number of polymer chains	2
Total formula weight	121784.58
Authors	Behnke, C.,Skene, R.J. (deposition date: 2012-09-28, release date: 2013-02-06, Last modification date: 2023-09-20)
Primary citation	Kono, M.,Matsumoto, T.,Kawamura, T.,Nishimura, A.,Kiyota, Y.,Oki, H.,Miyazaki, J.,Igaki, S.,Behnke, C.A.,Shimojo, M.,Kori, M. Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem., 21:28-41, 2013 Cited by PubMed: 23218778 DOI: 10.1016/j.bmc.2012.11.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.91 Å)

Structure validation