4HBP

Crystal Structure of FAAH in complex with inhibitor

4HBP の概要

• エントリーDOI: 10.2210/pdb4hbp/pdb
• 分子名称: Fatty-acid amide hydrolase 1, 4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide (3 entities in total)
• 機能のキーワード: fatty acid amide hydrolase, amidase activity, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121784.58

構造登録者

Behnke, C.,Skene, R.J. (登録日: 2012-09-28, 公開日: 2013-02-06, 最終更新日: 2023-09-20)

• 主引用文献: Kono, M.,Matsumoto, T.,Kawamura, T.,Nishimura, A.,Kiyota, Y.,Oki, H.,Miyazaki, J.,Igaki, S.,Behnke, C.A.,Shimojo, M.,Kori, M.; Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.; Bioorg.Med.Chem., 21:28-41, 2013; PubMed: 23218778; DOI: 10.1016/j.bmc.2012.11.006

実験手法

X-RAY DIFFRACTION (2.91 Å)