4HAR

Crystal Structure of Rubella virus capsid protein (residues 127-277)

4HAR の概要

• エントリーDOI: 10.2210/pdb4har/pdb
• 関連するPDBエントリー: 4HBE 4HBO
• 分子名称: Capsid protein, LAURYL DIMETHYLAMINE-N-OXIDE, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: partial beta barrel, capsid protein, viral protein
• 由来する生物種: Rubella virus (RUBV)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 106541.79

構造登録者

Mangala Prasad, V.,Fokine, A.,Rossmann, M.G. (登録日: 2012-09-27, 公開日: 2013-12-11, 最終更新日: 2024-11-06)

主引用文献

Mangala Prasad, V.,Willows, S.D.,Fokine, A.,Battisti, A.J.,Sun, S.,Plevka, P.,Hobman, T.C.,Rossmann, M.G.
Rubella virus capsid protein structure and its role in virus assembly and infection.
Proc.Natl.Acad.Sci.USA, 110:20105-20110, 2013

PubMed Abstract: Rubella virus (RV) is a leading cause of birth defects due to infectious agents. When contracted during pregnancy, RV infection leads to severe damage in fetuses. Despite its medical importance, compared with the related alphaviruses, very little is known about the structure of RV. The RV capsid protein is an essential structural component of virions as well as a key factor in virus-host interactions. Here we describe three crystal structures of the structural domain of the RV capsid protein. The polypeptide fold of the RV capsid protomer has not been observed previously. Combining the atomic structure of the RV capsid protein with the cryoelectron tomograms of RV particles established a low-resolution structure of the virion. Mutational studies based on this structure confirmed the role of amino acid residues in the capsid that function in the assembly of infectious virions.

PubMed: 24282305
DOI: 10.1073/pnas.1316681110

実験手法

X-RAY DIFFRACTION (2.663 Å)