4H96
Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)
4H96 の概要
エントリーDOI | 10.2210/pdb4h96/pdb |
関連するPDBエントリー | 3QLR 3QLS 3QLW 3QLX 3QLY 3QLZ 4H95 4H97 4H98 |
分子名称 | Dihydrofolate Reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-{3-[3-(1,3-benzodioxol-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine, ... (4 entities in total) |
機能のキーワード | antifungal agents, candida albicans, drug design, enzyme inhibitors, fungal proteins, tetrahydrofolate dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Candida albicans |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 45937.72 |
構造登録者 | |
主引用文献 | Paulsen, J.L.,Viswanathan, K.,Wright, D.L.,Anderson, A.C. Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species. Bioorg.Med.Chem.Lett., 23:1279-1284, 2013 Cited by PubMed: 23375226DOI: 10.1016/j.bmcl.2013.01.008 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
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