4H4O
Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with (E)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)- 4-fluorophenoxy)-5-fluorophenyl)acrylonitrile (JLJ506), A Non-nucleoside inhibitor
4H4O の概要
エントリーDOI | 10.2210/pdb4h4o/pdb |
関連するPDBエントリー | 1S9E 2BE2 2ZD1 4H4M |
分子名称 | Reverse transcriptase/ribonuclease H, Exoribonuclease H, p66 RT, Reverse transcriptase/ribonuclease H, Exoribonuclease H, p51 RT, (2E)-3-(3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-5-fluorophenyl)prop-2-enenitrile, ... (4 entities in total) |
機能のキーワード | polymerase, transferase, hydrolase/inhibitor, rnase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Human immunodeficiency virus type 1 BH10 (HIV-1) 詳細 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 114440.08 |
構造登録者 | |
主引用文献 | Frey, K.M.,Bollini, M.,Mislak, A.C.,Cisneros, J.A.,Gallardo-Macias, R.,Jorgensen, W.L.,Anderson, K.S. Crystal Structures of HIV-1 Reverse Transcriptase with Picomolar Inhibitors Reveal Key Interactions for Drug Design. J.Am.Chem.Soc., 134:19501-19503, 2012 Cited by PubMed: 23163887DOI: 10.1021/ja3092642 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.9 Å) |
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