4GVD

Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with Syndecan1 Peptide

4GVD の概要

• エントリーDOI: 10.2210/pdb4gvd/pdb
• 関連するPDBエントリー: 3KZD 3KZE 4GVC
• 分子名称: T-lymphoma invasion and metastasis-inducing protein 1, Syndecan-1, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: conformational change during phosphorylation, different binding pocket from phosphorylated sydencan1, scaffold signaling protein for cell adhesion and cell junction, sydencan1 n-terminal thr dansylation, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell junction: Q13009; Membrane; Single-pass type I membrane protein: P18827
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 22995.99

構造登録者

Liu, X.,Shepherd, T.R.,Murray, A.M.,Xu, Z.,Fuentes, E.J. (登録日: 2012-08-30, 公開日: 2013-03-13, 最終更新日: 2023-09-13)

• 主引用文献: Liu, X.,Shepherd, T.R.,Murray, A.M.,Xu, Z.,Fuentes, E.J.; The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.; Structure, 21:342-354, 2013; PubMed: 23395182; DOI: 10.1016/j.str.2013.01.004

実験手法

X-RAY DIFFRACTION (1.85 Å)