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4GUE

Structure of N-terminal kinase domain of RSK2 with flavonoid glycoside quercitrin

Summary for 4GUE
Entry DOI10.2210/pdb4gue/pdb
Related3UBD 4EL9
DescriptorRibosomal protein S6 kinase alpha-3, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsserine/threonine kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMus musculus (mouse)
Cellular locationNucleus (By similarity): P18654
Total number of polymer chains1
Total formula weight35639.58
Authors
Derewenda, U.,Utepbergenov, D.,Szukalska, G.,Derewenda, Z.S. (deposition date: 2012-08-29, release date: 2013-01-30, Last modification date: 2023-09-13)
Primary citationDerewenda, U.,Artamonov, M.,Szukalska, G.,Utepbergenov, D.,Olekhnovich, N.,Parikh, H.I.,Kellogg, G.E.,Somlyo, A.V.,Derewenda, Z.S.
Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 A resolution.
Acta Crystallogr.,Sect.D, 69:266-275, 2013
Cited by
PubMed: 23385462
DOI: 10.1107/S0907444912045520
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

数据于2024-03-27公开中

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