4GTD
T. Maritima FDTS (E144R mutant) with FAD and dUMP
Summary for 4GTD
Entry DOI | 10.2210/pdb4gtd/pdb |
Descriptor | Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | flavin-dependent thymidylate synthase, tm0449, e144r mutant, transferase |
Biological source | Thermotoga maritima |
Total number of polymer chains | 4 |
Total formula weight | 114501.97 |
Authors | Mathews, I.I.,Lesley, S.A.,Kohen, A.,Prabhakar, A. (deposition date: 2012-08-28, release date: 2012-10-17, Last modification date: 2023-09-13) |
Primary citation | Koehn, E.M.,Perissinotti, L.L.,Moghram, S.,Prabhakar, A.,Lesley, S.A.,Mathews, I.I.,Kohen, A. Folate binding site of flavin-dependent thymidylate synthase. Proc.Natl.Acad.Sci.USA, 109:15722-15727, 2012 Cited by PubMed: 23019356DOI: 10.1073/pnas.1206077109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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