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4GSY

Crystal structure of thymidylate kinase from Staphylococcus aureus bound to inhibitor.

4GSY の概要
エントリーDOI10.2210/pdb4gsy/pdb
関連するPDBエントリー4F4I 4HDC 4HEJ
分子名称Thymidylate kinase, 4-{[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl}-2-[3-(trifluoromethyl)phenoxy]benzoic acid (3 entities in total)
機能のキーワードtransferase, nucleotide binding, thymidylate kinase activity, atp binding, kinase activity, transferase activity, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Staphylococcus aureus subsp. aureus
タンパク質・核酸の鎖数2
化学式量合計47916.11
構造登録者
Larsen, N.A.,Olivier, N.B. (登録日: 2012-08-28, 公開日: 2012-10-24, 最終更新日: 2024-02-28)
主引用文献Martinez-Botella, G.,Breen, J.N.,Duffy, J.E.,Dumas, J.,Geng, B.,Gowers, I.K.,Green, O.M.,Guler, S.,Hentemann, M.F.,Hernandez-Juan, F.A.,Joseph-McCarthy, D.,Kawatkar, S.,Larsen, N.A.,Lazari, O.,Loch, J.T.,Macritchie, J.A.,McKenzie, A.R.,Newman, J.V.,Olivier, N.B.,Otterson, L.G.,Owens, A.P.,Read, J.,Sheppard, D.W.,Keating, T.A.
Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK).
J.Med.Chem., 55:10010-10021, 2012
Cited by
PubMed: 23043329
DOI: 10.1021/jm3011806
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.71 Å)
構造検証レポート
Validation report summary of 4gsy
検証レポート(詳細版)ダウンロードをダウンロード

222036

件を2024-07-03に公開中

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