4GQP

Structure based design of sub-nanomolar affinity anti-methamphetamine single chain antibodies.

4GQP の概要

• エントリーDOI: 10.2210/pdb4gqp/pdb
• 関連するPDBエントリー: 3GKZ
• 分子名称: Anti-METH scFv, (2S)-N-methyl-1-phenylpropan-2-amine (3 entities in total)
• 機能のキーワード: antibody meth complex, immunoglobulin fold, anti-meth single chain antibody, free meth concentration, methamphetamine, vasculature, immune system
• 由来する生物種: Mus musculus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26955.60

構造登録者

Thakkar, S.,Varughese, K.I. (登録日: 2012-08-23, 公開日: 2013-10-02, 最終更新日: 2023-09-13)

• 主引用文献: Thakkar, S.,Nanaware-Kharade, N.,Celikel, R.,Peterson, E.C.,Varughese, K.I.; Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering.; Sci Rep, 4:3673-3673, 2014; PubMed: 24419156; DOI: 10.1038/srep03673

実験手法

X-RAY DIFFRACTION (2 Å)