4GMX
Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1
Summary for 4GMX
Entry DOI | 10.2210/pdb4gmx/pdb |
Related | 4GPT |
Descriptor | GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (10 entities in total) |
Functional Keywords | heat repeat, protein export, crm1, kpt185, nuclear, protein transport-inhibitor complex, protein transport/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P62826 P30822 Cytoplasm: P41920 |
Total number of polymer chains | 3 |
Total formula weight | 163913.20 |
Authors | Sun, Q.,Chook, Y.M. (deposition date: 2012-08-16, release date: 2012-10-17, Last modification date: 2012-12-12) |
Primary citation | Lapalombella, R.,Sun, Q.,Williams, K.,Tangeman, L.,Jha, S.,Zhong, Y.,Goettl, V.,Mahoney, E.,Berglund, C.,Gupta, S.,Farmer, A.,Mani, R.,Johnson, A.J.,Lucas, D.,Mo, X.,Daelemans, D.,Sandanayaka, V.,Shechter, S.,McCauley, D.,Shacham, S.,Kauffman, M.,Chook, Y.M.,Byrd, J.C. Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood, 120:4621-4634, 2012 Cited by PubMed: 23034282DOI: 10.1182/blood-2012-05-429506 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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