4GMB

Crystal structure of human WD repeat domain 5 with compound MM-402

Summary for 4GMB

Entry DOI	10.2210/pdb4gmb/pdb
Related	4GM3 4GM8 4GM9
Related PRD ID	PRD_000896
Descriptor	WD repeat-containing protein 5, MM-402 (3 entities in total)
Functional Keywords	mll1, histone methyltransferase, wd40, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P61964
Total number of polymer chains	2
Total formula weight	35024.79
Authors	Karatas, H.,Townsend, E.C.,Chen, Y.,Bernard, D.,Cao, F.,Liu, L.,Lei, M.,Dou, Y.,Wang, S. (deposition date: 2012-08-15, release date: 2014-02-19, Last modification date: 2023-11-15)
Primary citation	Karatas, H.,Li, Y.,Liu, L.,Ji, J.,Lee, S.,Chen, Y.,Yang, J.,Huang, L.,Bernard, D.,Xu, J.,Townsend, E.C.,Cao, F.,Ran, X.,Li, X.,Wen, B.,Sun, D.,Stuckey, J.A.,Lei, M.,Dou, Y.,Wang, S. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J.Med.Chem., 60:4818-4839, 2017 Cited by PubMed: 28603984 DOI: 10.1021/acs.jmedchem.6b01796 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.781 Å)

Structure validation