4GHT
Crystal structure of EV71 3C proteinase in complex with AG7088
Summary for 4GHT
Entry DOI | 10.2210/pdb4ght/pdb |
Related | 4GHQ 4GHV 4GHX 4GHY 4GHZ |
Descriptor | 3C proteinase, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER (3 entities in total) |
Functional Keywords | hydrolase, cysteine proteinase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human enterovirus 71 |
Cellular location | Picornain 3C: Host cytoplasm (By similarity). Protein 3B: Virion (By similarity): A9XG43 |
Total number of polymer chains | 2 |
Total formula weight | 43984.32 |
Authors | |
Primary citation | Wu, C.,Cai, Q.,Chen, C.,Li, N.,Peng, X.,Cai, Y.,Yin, K.,Chen, X.,Wang, X.,Zhang, R.,Liu, L.,Chen, S.,Li, J.,Lin, T. Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir Acta Crystallogr.,Sect.D, 69:866-871, 2013 Cited by PubMed: 23633597DOI: 10.1107/S0907444913002862 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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