4GDB
SHV-1 in complex with 4H-pyrazolo[1,5-c][1,3]thiazole containing penem inhibitor
Summary for 4GDB
Entry DOI | 10.2210/pdb4gdb/pdb |
Related | 1Q2P 4GD6 4GD8 |
Descriptor | Beta-lactamase SHV-1, (7R)-6-formyl-7-(4H-pyrazolo[1,5-c][1,3]thiazol-2-yl)-4,7-dihydro-1,4-thiazepine-3-carboxylic acid, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (5 entities in total) |
Functional Keywords | class a beta-lactamase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 32824.86 |
Authors | Ke, W.,van den Akker, F. (deposition date: 2012-07-31, release date: 2013-07-31, Last modification date: 2017-11-15) |
Primary citation | Ke, W.,Pattanaik, P.,Bethel, C.R.,Sheri, A.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F. Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation Plos One, 7:e49035-e49035, 2012 Cited by PubMed: 23145056DOI: 10.1371/journal.pone.0049035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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