4GB9
Potent and Highly Selective Benzimidazole Inhibitors of PI3K-delta
Summary for 4GB9
Entry DOI | 10.2210/pdb4gb9/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-[1-({2-[2-(dimethylamino)-1H-benzimidazol-1-yl]-9-methyl-6-(morpholin-4-yl)-9H-purin-8-yl}methyl)piperidin-4-yl]propan-2-ol (3 entities in total) |
Functional Keywords | kinase p110 gamma-isoform, kinase, lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P48736 |
Total number of polymer chains | 1 |
Total formula weight | 111260.77 |
Authors | Murray, J.M. (deposition date: 2012-07-26, release date: 2012-08-22, Last modification date: 2023-09-13) |
Primary citation | Murray, J.M.,Sweeney, Z.K.,Chan, B.K.,Balazs, M.,Bradley, E.,Castanedo, G.,Chabot, C.,Chantry, D.,Flagella, M.,Goldstein, D.M.,Kondru, R.,Lesnick, J.,Li, J.,Lucas, M.C.,Nonomiya, J.,Pang, J.,Price, S.,Salphati, L.,Safina, B.,Savy, P.P.,Seward, E.M.,Ultsch, M.,Sutherlin, D.P. Potent and highly selective benzimidazole inhibitors of PI3-kinase delta. J.Med.Chem., 55:7686-7695, 2012 Cited by PubMed: 22877085DOI: 10.1021/jm300717c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.438 Å) |
Structure validation
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